Bleaching with 37.5% hydrogen peroxide lowers intensity of tooth sensitivity

Color change was evaluated by Student's t-test for independent samples. The absolute risk and intensity of TS were analyzed by Fisher's and Mann–Whitney/Friedman tests (p < 0.05).

The authors revealed that both treatment groups resulted in a significant tooth whitening 1 week post-bleaching. There were no significant differences between 37.5HP2 and 37.5HP3. Also, there were not differences between groups regarding high absolute risk (p = 1.0) and low intensity of TS at all time assessments.

Therefore, the authors concluded that "the in-office bleaching with two 37.5% HP applications produced the same whitening degree, risk and intensity of TS to that performed with three gel applications."

Furthermore, the authors discussed that clinicians should opt to use a neutral 37.5% HP in-office bleaching gel for two 8 min applications/clinical session because produces the same whitening effectiveness, risk and low intensity of TS as the protocol proposed by manufacturer (three 8 min applications).