No causal relationship between periodontitis and oral, gastric and oesophagal cancers, reveals study
There is no causal relationship between periodontitis and oral, gastric and oesophagal cancers, reveals a study published in the Australian Dental Journal.
Periodontitis is a common oral disease and the chronic inflammation caused by it may influence the development of cancers in the upper gastrointestinal tract. Many observational studies have established a relationship between the two, but the results are not entirely consistent.
Two-sample Mendelian randomization was performed using publicly available genome-wide association studies data for periodontitis, oral, gastric and oesophagal cancers. The Inverse Variance Weighting (IVW) method serves as the primary method, with Mendelian randomization Egger, Weighted Median, Simple Model and Weighted Model Algorithm methods as complementary methods to assess genetic causal associations.
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