Specialized proresolving mediators crucial for treating pulpal-periapical diseases: Study
Specialized proresolving mediators (SPMs) are crucial in the inception and treatment of pulpal-periapical diseases, suggests a study published in the Journal of Endodontics.
Proresolving lipid mediators are specialized molecules (SPMs) involved in the active resolution of the inflammatory process by regulating tissue homeostasis.
A group of researchers conducted a study to investigate the scientific literature to assess the potential of SPMs as an adjunct in the treatment of endodontic infection.
Three electronic databases (PubMed, Web of Science, and Scopus) were searched from their inception until February 2020 (PROSPERO CRD42020164743). Supplemental research was performed by screening the references of the relevant studies eligible for inclusion. A quality assessment of animal studies was performed using the Animal Research: Reporting of In Vivo Experiments guidelines, whereas the Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool was used to assess the risk of bias.
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