Use of glucocorticoids with NS tied with developmental abnormalities of teeth in kids
Long-term use of glucocorticoids in children with nephrotic syndrome is tied with the occurrence of developmental abnormalities of the teeth, according to a recent study published in the International Dental Journal.
Nephrotic syndrome (NS) is a clinical condition that occurs with proteinuria of severity that exceeds the compensating possibilities of the organism (50 mg/kg/d), due to increased permeability of glomerules for plasma proteins. A characteristic of NS is its recurrence, sometimes even every few months. Children mostly experience idiopathic NS as a result of minimal change disease, treated by glucocorticoids. The symptoms of the disease occur before the age of 12; the average age of development is between 3 and 5 years. The frequency of NS cases for children younger than 16 years old is estimated between 2 and 7 new cases for every 100,000 children. The average frequency is 16 cases for every 100,000 people.
Treatment with glucocorticoids in children with nephrotic syndrome can be the cause of developmental disorders of the masticatory organ and bone or teeth abnormalities. The aim was to assess the frequency and type of dental abnormalities and the correlation of their occurrence with a dosage of glucocorticoids and treatment time in children with idiopathic nephrotic syndrome.
The study group consisted of 31 patients aged 5 to 17 diagnosed with idiopathic steroid-sensitive nephrotic syndrome and 33 overall healthy children. The studies included clinical evaluation of dentition, radiologic diagnostics, and statistical analysis.
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