Effective dyslipidemia management may help preserve kidney function in individuals with diabetes: Study
China: A retrospective study published in Frontiers in Endocrinology suggests that effective management of dyslipidemia may help preserve kidney function in individuals with diabetes. The study found that elevated triglyceride levels and reduced high-density lipoprotein (HDL) levels were associated with a higher risk of albuminuria and a decline in estimated glomerular filtration rate (eGFR).
Lipid abnormalities are a common complication in diabetic kidney disease (DKD), contributing to disease progression and increasing cardiovascular risks. The researchers note that managing dyslipidemia in DKD is crucial, but conventional lipid-lowering therapies such as statins and fibrates have limitations, particularly concerning renal safety. Studies have linked dyslipidemia to an increased risk of atherosclerotic cardiovascular disease (ASCVD) and the progression of diabetic kidney disease, highlighting the potential role of early lipid management in preserving renal function.
Qian Ming Tu, Department of General Medicine, Shanghai Putuo District Changzheng Town Community Health Service Center, Shanghai, China, and colleagues conducted a retrospective study to explore the clinical characteristics of dyslipidemia, the mechanisms of lipid-induced renal injury, and recent advancements in lipid-lowering therapies for DKD.
For this purpose, the researchers conducted a literature search in PubMed, Web of Science, and EMBASE using specific keywords such as “diabetic kidney disease,” “diabetic nephropathy,” “diabetes,” “dyslipidemia,” “kidney,” “cardiovascular disease,” and “lipid therapy.”
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