Mixed meal test detects Gastric Bypass related Hypoglycemia Better than CGM

The researchers conducted a study at the General Clinical Research Unit, Cincinnati Children's Hospital, USA. They evaluated the glucose profiles of 15 patients with documented recurrent clinical hypoglycemia after gastric bypass, 8 matched asymptomatic GB patients and 9 healthy weight-matched nonoperated controls. The patients were subjected to MMT in a controlled setting followed by wearing a CGM for 4 to 5 days.

Key findings of the study:

• Upon analysis, the researchers found that the patients with prior GB had larger glucose variability during both MMT and CGMS when compared with nonsurgical controls regardless of their hypoglycemic status.
• They also found that MMT was superior to CGM use in detecting post-prandial hypoglycemia, with greater sensitivity (71%) and specificity (100%) compared with CGM (47% and 88%, respectively).

The authors concluded, "Our findings indicate that a fixed carbohydrate ingestion during MMT is a more reliable test to diagnose GB-related hypoglycemia compared with CGMS during free-living state."

For further information:

DOI: https://doi.org/10.1210/clinem/dgab913