R-Vera, a promising new antidiabetic medication? Study sheds light
Taiwan: In type 2 diabetes patients, the twice-daily addition of R-Vera to ongoing metformin therapy notably improved blood sugar patients, researchers state in a recent study in the Journal of Clinical Endocrinology & Metabolism. This implies that the favorable safety and efficacy profile of R-Vera 300 mg/day can be considered as a suitable dose for clinical practice.
There is a medical requirement for effective insulin-independent antidiabetic drugs in type 2 diabetes (T2DM) patients that have a low risk of hypoglycemia and promote pancreatic β-cell function, the researchers note. R-form verapamil (R-Vera) was shown to have the ability to enhance the survival of β-cells and has a higher margin of cardiovascular safety than verapamil. R-Vera was developed as a novel approach for the treatment of T2DM.
Against the above background, Wayne Huey-Herng Sheu, National Yang-Ming Chiao Tung University, Taipei, Taiwan, and colleagues designed a randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of 3 dosages of the addition of R-Vera in ongoing metformin therapy in T2DM patients having inadequate glycemic control on metformin alone.
For this purpose, the researchers randomly assigned the participants to receive an equal ratio of R-Vera 450, 300, or 150 mg per day, or a matching placebo, in combination with metformin. A change in hemoglobin A1c (HbA1c) after 12 weeks of treatment was the primary endpoint.
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