SGLT-2 inhibitors significantly lower risk of Atrial Fibrillation: Study
A recent review published in Diabetes, Obesity & Metabolism and based on a clinical trial suggests that there is a significantly lower risk of incident AF for individuals on SGLT‐2 inhibitor than placebo.
The ADA guidelines (2019) recommends that in patients with type 2 diabetes and atherosclerotic CV disease, sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1 receptor agonists (GLP-1) are recommended. SGLT-2 inhibitors are preferred in patients with athersclerotic CV disease who are at risk of heart failure or if heart failure coexists. Considering SGLT-2 inhibitor or GLP-1 receptor agonist in patients with type 2 diabetes and chronic kidney disease is advised as It has shown to reduce risk of chronic kidney disease progression, CV events or both.
Dapagliflozin is a sodium‐glucose cotransporter‐2 inhibitor (SGLT‐2i) that has recently been shown to reduce the incidence of reported episodes of atrial fibrillation (AF)/atrial flutter in the DECLARE‐TIMI 58 trial. This raises the question regarding whether SGLT‐2i can reduce the incidence of AF in a high‐risk population like in patients with type 2 diabetes and at risk for cardiovascular disease.
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