SGLT2 inhibitors with metformin do not increase fracture risk in diabetics: Study
Written By : Medha Baranwal
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2020-08-21 05:45 GMT | Update On 2020-08-21 12:26 GMT
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China: Combination therapy with SGLT2 inhibitors and metformin in patients with type 2 diabetes (T2D) does not increase fracture risk versus metformin monotherapy, according to a recent study in the journal Osteoporosis International.
According to the authors, no study has evaluated the association between sodium-glucose transporter-2 inhibitors (SGLT2is) and metformin use and fracture risk. Therefore the aim of this study by B-B. Qian, The Second Clinical College of Dalian Medical University, Yangzhou, Jiangsu, China, and colleagues was to investigate the fracture risk of SGLT2is and metformin combination therapy in T2D patients.
The researchers scrutinized online databases for all eligible randomized controlled trials (RCTs). The summarized odds ratios (ORs) and their 95% confidence intervals (CI) were calculated using Review Manager 5.3 software.
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