Stem Cell Therapy Shows Promise for Diabetic Foot: Umbrella Review
Stem cell therapy has emerged as a potential treatment for diabetic foot (DF), offering hope for improved healing rates, reduced amputation rates, enhanced vascular function, and alleviation of pain symptoms. However, the evidence regarding its effectiveness and safety has been fragmented. DF poses significant challenges in management due to its complex pathophysiology and potential for severe complications, including non-healing ulcers and amputations.
This umbrella review aims to summarize and evaluate the existing evidence from systematic reviews/meta-analyses (SRs/MAs) on the effectiveness of stem cell therapy for DF. This study was published in the journal Advances In Wound Care by Hongshuo Shi and colleagues. Stem cell therapy holds promise as a novel approach to address these issues by promoting tissue regeneration and angiogenesis.
Researchers conducted a comprehensive search for SRs/MAs that included randomized controlled trials (RCTs) on stem cell therapy for DF. Eight SRs/MAs were included in the review, and the methodological quality and evidence quality were evaluated. A quantitative synthesis of RCTs included in the SRs/MAs was performed to obtain updated conclusions.
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