Thiamine supplementation can prevent vascular complications in patients with diabetes
Pakistan: Researchers in a recent study published in Cureus recommend routine monitoring of serum thiamine levels in diabetic patients and suggest considering thiamine supplementation to avoid complications, especially vascular complications of diabetes mellitus (DM).
The study revealed that patients with type 1 and type 2 diabetes had significantly higher levels of fasting blood sugar (FBS), random blood sugar (RBS), triglycerides, glycated haemoglobin (HbA1c), and total cholesterol than control. Furthermore, serum thiamine and HDL levels were observed to be considerably lower in both type 1 and type 2 DM patients than those of controls. Also, there was a strong correlation between FBS and HbA1c among both types of diabetes mellitus and controls.
Thiamine, also known as vitamin B1, is a water-soluble vitamin that plays a critical role in the metabolism of both vital amino acids and carbohydrates. It has antioxidant and anti-inflammatory characteristics that affect endothelial function.
Previous studies have shown that low levels of thiamine reserves in the body are related to diabetes because thiamine directly impacts carbohydrate metabolism. Therefore, Atif A. Hashmi, Liaquat National Hospital and Medical College, Karachi, PAK, and colleagues aimed to assess several metabolic variables and blood thiamine levels in patients with type 1 and type 2 DM and compare them with those in a control group of healthy individuals in a case-control study conducted at multiple diabetic outpatient centres in Karachi.
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