TyG index significantly linked to heart failure with preserved ejection fraction, suggests study

A recent study published in the Frontiers in Endocrinology journal showed that heart failure with preserved ejection fraction (HFpEF) in patients with congenital heart disease (CHD) was shown to be significantly correlated with the triglyceride-glucose (TyG) index. Even with advancements in treatment, heart failure (HF) continues to place a heavy strain on the global healthcare system. Diabetes and a higher risk of metabolic and atherosclerotic cardiovascular diseases are positively correlated with the TyG index. Also, there has been evidence of a beneficial relationship between the prognosis of HF patients and the TyG index. Insulin resistance can be inferred from the triglyceride-glucose index. And so, Li Z and team carried out this study with to look if the TyG index and heart failure with preserved ejection fraction in patients with coronary heart disease (CHD) would be influenced by various metabolic conditions.

A total of 62,794 of the 107,301 CHD patients were included in order to examine the connection between HF and the TyG index. To distinguish between the various forms of heart failure, such as HF with decreased ejection fraction (HFrEF), HF with intermediate-range ejection fraction (HFmrEF), and HFpEF, 8,606 patients who had undergone echocardiography were included. 1896 of them had a diagnosis of HFpEF.

The association between the TyG index and HFpEF in patients with CHD was examined using logistic regression. Also, the correlation between the TyG index and HFpEF by age, sex, blood pressure, and blood lipids was evaluated. There were notable variations in the associated parameters among the four groups of CHD patients based on their tertile level of the TyG index, according to a baseline study. The TyG index was substantially linked to the probability of HFpEF in the multi-adjusted models.

TyG index values for T2 and T3 were linked to higher OR in HFpEF after multivariate correction. HFpEF in older persons over 60, hypertension, and dyslipidemia were all substantially correlated with the TyG index of CHD patients. Also, women's OR is greater than men's OR: 1.17; 95% CI: 1.02-1.22 which suggested a larger correlation between women's HFpEF and TyG index.

Overall, the results of this investigation showed that the TyG index and HFpEF were significantly correlated in patients with CHD. Among individuals with dyslipidemia, hypertension, and advanced age (>60 years), the TyG index was independently linked to HFpEF. Also, there were sex-specific differences in the relationship between the TyG index and HFpEF in CHD patients.

Source:

Li, Z., Fan, X., Liu, Y., Yu, L., He, Y., Li, L., Gao, S., Chen, W., Yang, R., & Yu, C. (2024). Triglyceride-glucose index is associated with heart failure with preserved ejection fraction in different metabolic states in patients with coronary heart disease. In Frontiers in Endocrinology (Vol. 15). Frontiers Media SA. https://doi.org/10.3389/fendo.2024.1447072