Omega-3 fatty acids supplements effective adjuvant therapy for children with diabetic nephropathy
Egypt: A recent study has shown the relevance of omega-3 fatty acids as an adjuvant therapy in pediatric type 1 diabetes mellitus (T1DM) patients with diabetic nephropathy in improving dyslipidemia, glycemic control, delayed disease progression and subclinical atherosclerosis. The findings from the randomized controlled trial were published in the journal Clinical Nutrition.
Several studies have assessed the omega-3 fatty acids' beneficial effects on autoimmune, inflammatory, and renal diseases. However, there is a lack of data on the effects of fatty acids on diabetic kidney disease in T1DM.
To address this knowledge gap, Nancy Samir Elbarbary, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt, and colleagues aimed to the effect of oral omega-3 supplementation on lipid profile, glycemic control, kidney injury molecule-1 (KIM-1), albuminuria level, and carotid intima-media thickness (CIMT) in pediatric patients with T1DM and diabetic nephropathy.
The study included seventy children with type 1 diabetes and diabetic nephropathy with a mean age of 15.2 ± 1.96 years and a median disease duration of 7 years. They were randomly assigned into two groups, the intervention group which received daily capsules of 1 g oral omega-3 fatty acids capsules. The other group received a matching placebo and served as a control group. Both groups were followed for 6 months with an assessment of CIMT, KIM-1, urinary albumin creatinine ratio (UACR), fasting lipids, and fasting blood glucose (FBG).
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