Buspirone benefits severe bloating but not postprandial fullness in gastroparesis
A Randomized Controlled Trial published in Alimentary Pharmacology & Therapeutics by Dr Henry P Parkman has concluded that Treating with the 5-HT1 receptor agonist buspirone in patients with gastroparesis falls short of reducing symptoms, including moderate-to-severe early satiety/postprandial fullness.
It is already known that gastroparesis patients and those with related disorders have early satiety, postprandial fullness and bloating. To improve fundic accommodation, Buspirone, a 5-HT1 receptor agonist, may be used.
Considering this background, in the present study, researchers determined whether Buspirone improves early satiety and postprandial fullness in gastroparesis patients.
The study included patients presenting with symptoms of gastroparesis and moderate-to-severe symptoms of fullness. 10 mg of Buspirone was given orally, while the placebo thrice daily. The primary outcome was a change in the ES/PPF from baseline to 4 weeks.
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