High Dose of Oral thiamine Effective for Treating Chronic Fatigue of IBD
Fatigue is a burdensome symptom for patients with inflammatory bowel disease (IBD) even with IBD in remission. In a recent study, researchers of the Aarhus University Hospital, Denmark have found that high-dose of oral thiamine have a significantly superior effect on chronic fatigue in IBD when compared with placebo. The study findings were published in the journal Alimentary Pharmacology & Therapeutics on November 18, 2020.
The prevalence of fatigue in patients with IBD varies from 15% to 54%. Patients with Crohn's disease, Ulcerative colitis and gender female are more likely to develop Chronic fatigue (fatigue more than 6 months). however, only a few pharmacological interventions have documented effect on fatigue in patients with IBD. Thiamine is essential for carbohydrate metabolism and production of mitochondrial ATP production. As thiamine is a water-soluble vitamin with renal clearance, the risk of thiamine accumulation is limited for patients with normal kidney function. Previous studies have shown no toxicity effect of thiamine after 4 weeks of high dose intake. High dose of thiamine intake for weeks induces passive diffusion into the cell which may have some effect on relieving fatigues. To test this hypothesis, researchers conducted a study to investigate the effect and safety of high‐dose oral thiamine (600‐1800 mg/d) based on gender and weight on chronic fatigue in patients with quiescent IBD.
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