Liver Fibrosis may Increase mortality risk among in patients of Ischemic Stroke

Key highlights of the research:

• Patients who had experienced a severe stroke showed a higher FIB-4 index than those who had not (2.7± 1.7 and 2.3 ± 1.4, respectively).
• Age (relative risk (RR) 1.064, 95% confidence interval (CI) 1.030-1.100, p < 0.001), female gender (RR 1.723, 95% CI 1.100-2.698, p = 0.012), atrial fibrillation (RR 1.869, 95% CI 1.234-2.831, p = 0.002), diastolic blood pressure (DBP) (RR 1.019, 95% CI 1.006-1.033, p = 0.001), and the FIB-4 index (RR 1.130, 95% CI 1.007-1.268, p = 0.022) were the independent risk predictors for severe IS.
• 64.2% of individuals were dependent at discharge.
• At the time of discharge, there was no difference in the FIB-4 index among subjects who were dependent versus those who were independent (2.3 ±1.5 and 2.1± 1.2, respectively; p = 0.061).
• 9.8% of patients passed away while they were in the hospital.
• Compared to those who were discharged, individuals who passed away in the hospital had a higher FIB-4 index (2.9± 1.8 vs. 2.3± 1.4, respectively).
• DBP, serum glucose levels, serum triglyceride levels, NIHSS, and the FIB-4 index were the independent risk factors for in-hospital mortality.

The authors concluded that the risk of acute ischemic stroke is more severe, and having a worse outcome is increased by hepatic fibrosis.

REFERENCE

Ztriva, Eleftheria, et al. "Hepatic Fibrosis Is a Risk Factor for Greater Severity and Worse Outcome of Acute Ischemic Stroke." Journal of Clinical Medicine, vol. 11, no. 17, 2022.