Metabolic dysfunction increases risk for steatosis and fibrosis development: Study
USA: In a new study published in Clinical Gastroenterology and Hepatology, it was shown that metabolic dysfunction, as defined by the metabolic-associated fatty liver disease (MAFLD) criteria, is a major risk factor for steatosis and fibrosis development.
The MAFLD criteria are intended to capture the disease's heterogeneity in order to improve patient categorization and therapy. However, as is well known, the metabolic parameters utilized in nomenclature are complicated and linked, and their nuanced contribution to the definition must be evaluated in order to appropriately quantify clinical significance and stratify the at-risk group.
Kajal Claypool and colleagues used two models, one for each metabolic component, to investigate the relative predictive relevance of the seven core metabolic parameters described by the MAFLD criteria for steatosis and fibrosis outcomes in a nationally representative cohort, NHANES 2017-2018. They defined hepatic steatosis as the median liver stiffness evaluated by vibration-controlled transient elastography, and fibrosis as the controlled attenuation parameter (CAP) at the higher sensitivity cut-off point. All of the models were adjusted for diabetes, obesity, ethnicity, age, and gender.
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