Mixed Dietary Impact on IBD: Potatoes Lower Crohn's Risk but Raise Ulcerative Colitis Risk
Researchers have found in a large European cohort study that a higher intake of fruits, vegetables, legumes, and potatoes was associated with a reduced risk of Crohn's disease. However, high potato consumption alone was linked to an increased risk of ulcerative colitis. Researchers suggest these findings may be particularly important for children and first-degree relatives of individuals with inflammatory bowel disease. The study was published in The American Journal of Gastroenterology by Meyer A. and colleagues.
The EPIC cohort involved 341,519 participants from Europe and was followed up prospectively for 13.4 years. All subjects had used validated food frequency questionnaires at baseline to record their consumption of fruits, vegetables, legumes, and potatoes. Based on food eating habits, researchers estimated CD and UC risk using Cox proportional hazard models. These models were stratified for center, sex, and age, and adjusted for a number of factors such as smoking status, body mass index (BMI), physical activity, energy intake, educational level, and alcohol use.
Key Findings
149 of the total participants developed Crohn's disease and 379 developed ulcerative colitis during follow-up. The study identified a number of key associations:
• Participants in the highest quartile of total fruit, vegetable, legume, and potato consumption had a 56% lower risk of developing CD compared to those in the lowest quartile (adjusted hazard ratio [aHR] = 0.44; 95% CI: 0.26–0.76; p-trend < 0.01).
• No significant protective association was observed between the same dietary group and UC risk (aHR = 1.07; 95% CI: 0.76–1.50; p-trend = 0.73).
• Individual pooled intake of apple/pear, banana, mushroom, and onion/garlic was associated with a 42% decreased risk of CD comparing the upper to lower quartile (aHR = 0.58; 95% CI: 0.33–1.02; p-trend = 0.03).
• On the other hand, a 51% higher risk of UC was reported in those with the highest quartile of potato intake compared to the lowest (aHR = 1.51; 95% CI: 1.05–2.17).
• A composite diversity score incorporating consumption from fruit, vegetables, legumes, and potatoes had no significant correlation with the risk of either CD or UC.
The research concludes that increased consumption of apple/pear, banana, mushrooms, and onion/garlic lowers the risk of developing Crohn's disease, while increased consumption of potatoes enhances the risk of ulcerative colitis. These findings show the possibilities of specific diet changes in the prevention of inflammatory bowel diseases, especially Crohn's disease, by means of greater consumptions of certain plant foods.
Reference:
Meyer, Antoine MD PhD1,2,a; Carbonnel, Franck MD PhD1,2; Dahm, Christina C PhD3; Halkjær, Jytte PhD4; Tjønneland, Anne MD PhD DMSc4,5; Schulze, Matthias B DrPH6,7; Sacerdote, Carlotta8,9; Tumino, Rosario MD MSc DLSHTM10; Oldenburg, Bas MD PhD11; Huerta, José M PhD12,13; Guevara, Marcela MD PhD14,15,16; Aune, Dagfinn PhD17,18,19; Gunter, Marc J PhD17,20; Heath, Alicia K PhD17; Vineis, Paolo PhD17; Tong, Tammy Y N PhD20; Amiot, Aurélien MD PhD1,2; Chan, Simon S M MB BChir PhD21,22. Fruits, vegetables, legumes and potatoes and risk of Crohn’s disease and ulcerative colitis. The American Journal of Gastroenterology ():10.14309/ajg.0000000000003602, June 24, 2025. | DOI: 10.14309/ajg.0000000000003602
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.