Triglycerides to HDL cholesterol ratiomay reliably predict hyperlipidaemic acute pancreatitis

CHINA: According to a study published in the Journal of Hepato-Biliary-Pancreatic Sciences, the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) is strongly linked to the severity of hyperlipidemic acute pancreatitis (HTGP) and may be used as a definitive indicator of severe HTGP.

Acute pancreatitis brought on by hyperlipidemia is becoming more common. To increase patient prognosis and lower mortality, it's critical to make a prompt and simple determination of the severity of hyperlipidemic acute pancreatitis (HTGP). As per earlier research, acute pancreatitis and insulin resistance (IR) are related.

The goal of the study was to determine whether the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and HTGP are correlated.

The institutional pancreatitis database was accessed for this purpose in order to gather the patients' laboratory and clinical parameters. 134 (46.2%) of the 290 patients had a diagnosis of severe HTGP. The effectiveness of four clinical grading systems— Ranson's Criteria, Acute Physiology and Chronic Health Evaluation II (APACHE II), the Bedside Index for Severity in Acute Pancreatitis (BISAP), and Marshall. —as well as risk factors for the severity of HTGP were assessed using univariate and multivariate logistic regression analyses.

Major highlights of the study:

• In comparison to the mild HTGP subgroup, the moderate-to-severe HTGP subgroup had a greater TG/HDL-C ratio.
• The TG/HDL-C ratio exhibited the largest area under the curve (AUC) (0.727, 95% CI, 0.571-0.701) among the independent risk indicators, such as amylase, albumin, aspartate transaminase (AST), systemic inflammatory response syndrome (SIRS), and TG/HDL-C ratio.
• The TG/HDL-C ratio has a substantially better prognostic ability when compared to other clinical grading systems.

A simple marker of severe HTGP could be the TG/HDL-C ratio, which has a positive correlation with the condition's severity, concluded the researchers.

REFERENCE

Su, N., Zhu, Y., Peng, Y., Xia, W., Chen, L., Yu, H., Shi, L., Yang, Y. and Huang, Y. (2022), Triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an independent predictor of the severity of hyperlipidaemic acute pancreatitis. J Hepatobiliary Pancreat Sci. Accepted Author Manuscript. https://doi.org/10.1002/jhbp.1281