Clinical trial finds novel therapy markedly reduced lipoprotein(a) levels in people with cardiovascular disease

The trial included 227 patients who received one of four doses of olpasiran and 54 who received a placebo. They found that patients who received higher doses of olpasiran had more than a 95% drop in lipoprotein(a) over 36 weeks compared to placebo. The treatment was not associated with serious side effects apart from occasional injection site swelling and related mild reactions.

Researchers said these study results show that marked and sustained reduction of lipoprotein(a) is possible through RNA interference using olpasiran, These findings set the stage for a much larger phase 3 trial to definitively evaluate if lowering lipoprotein(a) translates into better outcomes.

Researchers concluded that olpasiran is a very promising therapy for individuals with high lipoprotein(a) levels who currently don't have any effective therapies to lower its concentration.

Reference:

Clinical trial finds novel therapy markedly reduced lipoprotein(a) levels in people with cardiovascular disease; BRIGHAM AND WOMEN'S HOSPITAL, JOURNAL: New England Journal of Medicine