The research team applied nanosecond laser texturing technology to create nano- and micro-scale wrinkle patterns on nickel-titanium alloy surfaces. The wrinkle patterns inhibit the migration and morphological changes of smooth muscle cells caused by stent-induced vascular wall injury, preventing restenosis. The wrinkle patterns also enhance cellular adhesion, promoting re-endothelialization to restore the vascular lining.
The team validated the effectiveness of this technology through in vitro vascular cell studies and ex vivo angiogenesis assays using fetal animal bones. The laser-textured metal surfaces created favorable environments for endothelial cell proliferation while effectively suppressing smooth muscle cell dedifferentiation and excessive growth. Notably, smooth muscle cell growth on the wrinkled surfaces was reduced by approximately 75%, while angiogenesis increased more than twofold.
The surface patterning technology is expected to be applicable not only to metal stents but also to biodegradable stents. When applied to biodegradable stents, the patterns can prevent restenosis and enhance endothelialization before the stents dissolve, improving treatment outcomes and reducing complication risks.
Dr. Jeon stated, “This study demonstrates the potential of surface patterns to selectively control vascular cell responses without drugs. Using widely industrialized nanosecond lasers allows for precise and rapid stent surface processing, offering significant advantages for commercialization and process efficiency.”
Reference: Jun, I., Choi, H., Kim, H., Choi, B. C., Chang, H. J., Kim, Y., ... & Jeon, H. (2025). Exploring the potential of laser-textured metal alloys: Fine-tuning vascular cells responses through in vitro and ex vivo analysis. Bioactive Materials, 43, 181-194.
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