New study links IgG immunoglobulin's glycan coating with cardiovascular health
A recent study from Brigham and Women's Hospital, a founding member of Mass General Brigham, has found that while cholesterol is a major contributor to heart disease, a glycan biomarker of IgG is also an important predictor for cardiovascular diseases (CVD).
The glycan sugar coating on IgG immunoglobulin plays a crucial role in modulating immune responses and maintaining overall health. This coating, consisting of complex sugar molecules attached to the protein structure of IgG, influences various aspects of immune function, including antibody stability, binding affinity, and interaction with immune cells. Alterations in the glycan composition of IgG have been linked to various diseases, including autoimmune disorders, infectious diseases, and cancer.
The researchers studied the sugar coatings on an antibody known as immunoglobulin G (IgG), which is implicated in the immune responses associated with chronic inflammation among participants in two case-control studies.Using conditional logistic regression, they investigated the association of future CVD with baseline IgG N-glycans and a glycan score adjusting for clinical risk factors such as statin treatment, age, sex, race, lipids, hypertension, and smoking. Using least absolute shrinkage and selection operator regression, an IgG glycan score was derived as a linear combination of selected IgG N-glycans.
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