Semaglutide may protect Kidneys in Overweight Patients with Heart Disease, Study finds
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In a groundbreaking study published in the New England Journal of Medicine, researchers discovered that semaglutide significantly reduces risk of major kidney disease events, cardiovascular outcomes, and mortality in patients with type 2 diabetes and chronic kidney disease.
The results were presented at the 61st ERA Congress.
Chronic kidney disease (CKD) impacts more than 800 million people around the world, especially those with type 2 diabetes. CKD can lead to serious issues like kidney failure, heart problems, and even death.
Although current treatments help protect the kidneys and lower heart risks, many people still suffer from worsening kidney function and other health problems. This situation has increased interest in finding new treatments, including drugs called GLP-1 receptor agonists.
In the study, 3,533 patients were analyzed from the FLOW study, a double-blind, randomized, placebo-controlled international trial with a median follow-up period of 3.4 years. The trial aimed to evaluate the efficacy and safety of semaglutide, a once-weekly subcutaneous glucagon-like peptide 1 (GLP-1) receptor agonist, in preventing major kidney outcomes, such as kidney failure, significant loss of kidney function, and death from kidney or cardiovascular causes, in individuals with type 2 diabetes and chronic kidney disease. Participants received either semaglutide 1.0 mg once weekly or a placebo.
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