Genetically Tailored Diet: Future of Diet Management in IBS Patients? Study Reveals Insights
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An international study has found that genetic variations in human carbohydrate-active enzymes may affect how people with irritable bowel syndrome (IBS) respond to a carbohydrate-reduced diet.
The research, which is published in Clinical Gastroenterology & Hepatology, shows that irritable bowel syndrome patients with genetic defects in carbohydrate digestion had a better response to certain dietary interventions. This could lead to tailored treatments for IBS, using genetic markers to predict which patients benefit from specific diets.
Nutrigenetics has highlighted how changes in the DNA can affect the way we process food. Now, this pioneering new study suggests that genetic variations in human carbohydrate-active enzymes (hCAZymes) may similarly affect how irritable bowel syndrome patients respond to a carbohydrate-reduced (low-FODMAP) diet.
The team have now revealed that individuals with hypomorphic (defective) variants in human carbohydrate-active enzymes genes are more likely to benefit from a carbohydrate-reduced diet.
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