Study Reveals Novel Drug in Reducing Corticosteroid Dependence for CAH Patients
Advertisement
Researchers at the U-M Medical School have found a new medicine, crinecerfont, that might help people with congenital adrenal hyperplasia (CAH) to take fewer corticosteroids.
The study was published in the New England Journal of Medicine.
People born with a common type of congenital adrenal hyperplasia don't have an enzyme in their adrenal glands that helps make certain hormones. These hormones, called cortisol and aldosterone, are important for dealing with stress and regulating blood pressure.
Because their bodies lack this enzyme, children with this condition end up making too many male hormones, known as androgens. This can cause them to grow up faster than usual and have short stature and trouble having children when they're adults.
Even a regular stomach bug can be dangerous for people with this condition. It can cause something called an adrenal crisis, which can lead to shock if not treated quickly. The go-to therapy for children and adults with CAH are high high-dose corticosteroids, which come with a host of side effects, including weight gain, diabetes, osteoporosis, and cognitive dysfunction.
Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.