Predictive Biomarkers May Support Potential for "Personalized Medicine Approach" in RA Patients, Study Reveals
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A study published by researchers in Trinity College Dublin and St Vincent's University Hospital proposes a better understanding of the site of inflammation in rheumatoid arthritis which will allow for the development of new treatment strategies or predictive biomarkers which could support the potential for a ‘personalised medicine’ approach. The study was published in the journal Science Advances. In India, the prevalence of rheumatoid arthritis is estimated to be 0.7% which is higher than the global prevalence of 0.46%
The team performed an in-depth investigation of a specific population of cells: ‘the macrophages’ that reside in the synovium of Rheumatoid arthritis patients, ‘individuals-at-risk’ of RA, and healthy controls. Researchers demonstrated for the first time, the presence of a dominant macrophage subtype (CD40-expressing CD206+CD163+) in the inflamed Rheumatoid arthritis synovium, which importantly was associated with disease activity and treatment response.
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