Daprodustat noninferior to darbepoetin alfa for anemia in CKD patients on dialysis: JAMA
USA: Results from a recent study in JAMA Internal Medicine show that daprodustat is noninferior to darbepoetin alfa for treating anemia of chronic kidney disease (CKD) in incident dialysis (ID) patients. Based on this, the authors suggest that daprodustat may represent an oral alternative to a conventional erythropoiesis-stimulating agent in ID patients.
Daprodustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor. It is being evaluated as an oral alternative to conventional erythropoiesis-stimulating agent (ESA) therapy. However, not many studies of anemia treatment in an ID population have been reported. Considering this, Ajay K. Singh, Brigham and Women's Hospital, Boston, Massachusetts, and colleagues aimed to evaluate the safety and efficacy of daprodustat vs darbepoetin alfa in treating anemia of CKD in ID patients in a prospective, randomized, open-label clinical trial.
The trial was conducted from May 11, 2017, through September 24, 2020, in 90 centers across 14 countries. Eligibility criteria were patients with advanced CKD if they planned to start dialysis within 6 weeks from screening or had started and received hemodialysis (HD) or peritoneal dialysis (PD) within 90 days before randomization, had screening hemoglobin (Hb) concentration of 8.0 to 10.5 g/dL (to convert to grams per liter, multiply by 10) and a randomization Hb of 8.0 to 11.0 g/dL, were ESA-naive or had received limited ESA treatment, and were iron-replete.
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