Elevated non-HDL-C linked to higher mortality in patients undergoing peritoneal dialysis: Study
China: An increased level of non-HDL-C raises the risk of cardiovascular (CV) mortality and all-cause mortality in patients undergoing peritoneal dialysis (PD), researchers report in a recent study in the Journal of Clinical Lipidology.
Peritoneal dialysis is a treatment for kidney failure that used the abdomen lining (called peritoneum), or, belly for filtering blood inside the body. Fengxian Huang, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China, and colleagues aimed to evaluate the association of non-HDL-C with cardiovascular and all-cause mortality in PD patients in a prospective cohort study.
The study included a total of 1,616 incident PD patients from a single PD center in South China. They were followed for a median of 47.6 months. Cox regression analysis was used to evaluate the independent association of non-HDL-C with CV and all-cause mortality.
Upon analysis, the researchers found that:
· During the follow-up period, 31.4% patients died, of which 49.0% were due to CV events.
· Atherosclerotic CV mortality accounted for 59.8% of CV mortality.
· In multivariable models, for 1-SD increase in non-HDL-C level, the hazard ratios (HRs) for CV and all-cause mortality were 1.52 and 1.24 respectively.
· Non-HDL-C was positively associated with atherosclerotic CV mortality (HR, 1.29) but not associated with nonatherosclerotic CV mortality (HR, 0.79).
· The quartile analyses showed a similar pattern to the continuous variable analyses of non-HDL-C levels for CV and all-cause mortality but did not demonstrate statistical significance for atherosclerotic or nonatherosclerotic CV mortality.
"Our findings demonstrated that an elevated non-HDL-C level was independently associated with an increased risk of CV mortality, especially atherosclerotic CV mortality, and all-cause mortality in incident PD patients," concluded the authors.
Reference:
The study titled, "Non-high-density lipoprotein cholesterol and mortality among peritoneal dialysis patients," is published in the Journal of Clinical Lipidology.
DOI: https://www.lipidjournal.com/article/S1933-2874(21)00114-8/fulltext
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