Neurological dysfunction tied to ischemic injury to kidneys in type 1 diabetes patients

The study demonstrated the following findings:

• Higher mTCNS was associated with lower renal blood flow (β ± SE:−9.29 ± 4.20) and greater RE (β ± SE:32.97 ± 15.43) in participants with T1D but not in controls.
• DKD non-resistors had higher mTCNS and worse corneal nerve morphology measures than those without DKD.
• Renal hemodynamic parameters did not associate with autonomic nerve function.

"The findings suggest that neurological dysfunction in diabetes presence may be associated with impaired renal blood flow leading to ischemic injury in type 1 diabetes patients," the researchers wrote in their conclusion. "Early autonomic dysfunction does not seem to contribute to the neurologic dysfunction observed in this cohort of patients."

Reference:

Lytvyn Y, Albakr R, Bjornstad P, Lovblom LE, Liu H, Lovshin JA, Boulet G, Farooqi MA, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI. Renal hemodynamic dysfunction and neuropathy in longstanding type 1 diabetes: Results from the Canadian study of longevity in type 1 diabetes. J Diabetes Complications. 2022 Sep 28;36(11):108320. doi: 10.1016/j.jdiacomp.2022.108320. Epub ahead of print. PMID: 36201892.