According to news reports, the deceased have been identified as S. Sarooban (23) of Coimbatore, P. Rahul Jebastian (23) of Pudukottai, and S. Mukilan (23) of Tirupattur.
All three were pursuing their medical training at TKGMCH.
The injured, R. Kiruthikkukmar (23) of Thoothukudi and Saran (23) of Tirupattur, are undergoing treatment in the hospital, news agency PTI reported.
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According to the police, the accident took place around dawn when the group of five, travelling in a sedan driven by Sarooban, was heading along the rain-drenched South Beach Road.
Preliminary investigations suggest that the car was moving at high speed when it skidded on the slippery surface.
The driver reportedly lost control while negotiating a curve near a barricade, causing the vehicle to veer off the road and crash violently into a roadside tree.
Passers-by alerted the Thoothukudi South Police and Fire and Rescue Services personnel, who quickly rushed to the spot and began rescue operations.
The impact of the collision had severely damaged the vehicle, and officers had to carefully extract the injured from the mangled car.
Satnam and Rahul Jebastian were declared dead on the spot due to the severity of their injuries.
Mukilan, who was critically injured, was immediately shifted to TKGMCH along with the two survivors.
However, doctors said he suffered a sudden cardiac arrest within minutes of arrival and could not be revived despite emergency efforts, reports PTI.
Kiruthikkukmar and Saran, both sustaining multiple injuries, are currently being treated in the Intensive Care Unit.
Hospital sources described their condition as serious but stable.
The Thoothukudi South Police have registered a case and launched an investigation.
Authorities are examining whether overspeeding, poor visibility or slippery road conditions post overnight rain contributed to the accident.
The incident has cast a pall of gloom over the TKGMCH campus, where fellow students and faculty members mourned the sudden loss of three promising young doctors whose careers had just begun.
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