Pfizer, Alloy Therapeutics unite on new antibody discovery platform

"Alloy’s ATX-Gx platform has rapidly become the industry standard for fully humanized transgenic mice, being used by over 170 partners and in turn enabling many therapeutic discovery programs. Alloy is dedicated to reinvesting its revenue into innovation and has continuously expanded its murine platforms, adding new strains such as ATX-GL with the full human lambda repertoire, as well as ATX-GKHTM hyperimmune strain for increased generation of antigen-specific B-cells and enhanced IgG class switching," the release stated.

Pfizer and Alloy have collaborated on various antibody discovery efforts, including the use of Alloy's ATX-CLC platform. Launched in 2023 and accessible through Alloy's Antibody Discovery Services unit, the ATX-CLC platform enables the expression of common light chain antibodies with full heavy chain diversity, thereby facilitating efficient and modular bispecific antibody discovery.

"Our Cambridge, UK research team has developed a cutting-edge workflow for generating transgenic animal models, strengthening Alloy's position as a leader in this area of drug discovery," said Davide Schiavone, Head of Genetically Engineered Organisms at Alloy Therapeutics. "By collaborating with industry leaders like Pfizer, we help to ensure our platforms are built for what scientists truly need—solutions that streamline the drug discovery process. Our commitment to continuous innovation is rooted in collaboration, and we firmly believe the best way to build technologies of the future is to create them hand-in-hand with our partners when possible."