Zydus to launch Desidustat breakthrough treatment for Anemia in CKD patients under brand name Oxemia

Speaking on the development, Pankaj R. Patel, Chairman, Zydus Lifesciences Ltd., said, "Our life changing discoveries are guided by the need to help patients lead a better life and empower them with therapies that enable them to live healthier and more fulfilled lives. There was a potential for an oral, safer alternative to currently available injectable erythropoietin- stimulating agents (ESAs). After more than a decade of research and development into the science of HIF-PH inhibitors, results have demonstrated that Oxemia (Desidustat) addresses this unmet need and additionally reduces hepcidin, inflammation and enables better iron mobilisation. This advancement offers ease of convenience for the patient and will also reduce the disease burden by providing treatment at an affordable cost, thereby improving the quality of life for patients suffering from Chronic Kidney Disease."

Zydus is amongst the top players in the Nephrology segment with a super-specialty portfolio with brands like Zyrop, Grafalon, Tacromus and Mycomune. With Oxemia, the group posts a new milestone in its innovation journey which has seen the commercialization of several novel therapies.

Chronic kidney disease (CKD) is a serious progressive medical condition characterized by a gradual loss of kidney function, usually accompanied by other comorbidities including anemia, cardiovascular diseases (hypertension, heart failure and stroke), diabetes mellitus, eventually leading to kidney failure. CKD patients are often on multiple medications and are at safety risks of drug-drug interactions.

It has been reported that 115.1 million people in India, 132 million in China, 38 million in the United States, 21 million in Japan and 41 million people in Western Europe are estimated to be living with Chronic Kidney Disease. CKD is predicted to become one of the most common causes of premature death by 2040 globally.

Results of multiple studies of Oxemia (Desidustat) have been published in various international peer-reviewed scientific journals of repute such as American Journal of Nephrology, Clinical Pharmacokinetics, European Journal of Pharmacology, Journal of Medicinal Chemistry, Drug Development Research, Drug Research (Stuttg) and Xenobiotica.

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