Pelvic organ prolapse not associated with low bone mineral density: The HUNT study

Women with a hospital diagnosis of stress urinary incontinence (SUI) were less likely to have osteopenia or osteoporosis compared with women without a diagnosis of SUI. In women with self-reported information on pelvic floor disorders, women with a history of SUI had lower odds for osteopenia or osteoporosis, while no association was found between anal incontinence, self-reported surgery for pelvic organ prolapse, and osteopenia or osteoporosis.

In this population-based, cross-sectional study of 6809 women, POP and anal incontinence were not associated with low BMD. Unexpectedly, diagnosis, surgical treatment and self-reported symptoms of SUI were associated with decreased odds of osteopenia or osteoporosis. The present results, although limited by low numbers, did not indicate that the association between POP and BMD may vary according to type of prolapse. A lack of association between faecal incontinence and bone strength was also found in a cross-sectional study based on 681 postmenopausal women undergoing osteoporosis evaluation. The present results suggest that SUI is associated with lower risk of osteopenia or osteoporosis.

It has been hypothesized that PFDs may be linked to lower bone strength through common pathophysiological pathways of connective tissue deficiency or low oestrogen. The lack of association between PFDs and lower BMD in this study suggests that PFDs may not reflect skeletal compromise.

Overall, this study did not find associations between POP and BMD. The findings suggest that women with symptoms of urinary incontinence or a history of surgical treatment for urinary incontinence are less likely to have low BMD. The reasons underlying the observed association between SUI and BMD require further investigation. This study did not find evidence to suggest that women with PFDs would benefit from earlier evaluation for osteoporosis.

Source: S. Aspli et al; European Journal of Obstetrics & Gynecology and Reproductive Biology 271 (2022) 71–76

https://doi.org/10.1016/j.ejogrb.2022.02.002