Pregnancies complicated by preeclampsia linked to decreased serum maternal level of pregnancy specific glycoprotein 1: Study
Preeclampsia [PE] is a multiple system pathology of pregnancy defined previously as hypertension associated with proteinuria after 20 weeks of pregnancy.
Pregnancy-specific glycoproteins (PSGs), known as Schwangerschafts Protein and pregnancy-specific beta 1 glycoproteins, are a family of soluble proteins released by the placental syncytiotrophoblasts during pregnancy. PSGs have been detected as early as 3 days post fertilization in the maternal serum, with the attachment of the blastocyst to the uterine wall, and then the level increases gradually and reaches to the level of 200 400 µg/mL in the third trimester, while in the fetal serum, its level does not exceed 1-2 µg/L. PSGs can control the secretion of proangiogenic factors, TGF-β1 and VEGF A, by various types of cell included in placental development. The provision of an immunomodulator environment and The stimulation of angiogenesis in the maternal–foetal interface indicate that PSGs are effective in progress of pregnancy and successful outcomes.
Studies Previously have revealed that the level of PSG is abnormal in complicated pregnancies and illustrate the role of this protein for protect healthy pregnancies so, it is clear that the PSG level in serum diminished with complicated pregnancy outcome abortion, ectopic pregnancy, fetal hypoxia and intrauterine growth retardation. This study aimed to detect the relationship between PSG levels and preeclampsia by comparing serum PSG levels between pregnant with preeclampsia and normotensive healthy pregnants, and since the PSG1 mRNA is fairly expressed highly compared with other PSGs in the pregnancy first trimester and in the term placenta.
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