Pregnancies complicated by preeclampsia linked to decreased serum maternal level of pregnancy specific glycoprotein 1: Study

A total of 90 pregnant women, whom were recruited during their antenatal care visits to the obstetrical department in Hospital, were included. They were divided into two groups: 45 women with diagnosis of preeclampsia and 45 controls who were the women with healthy pregnancy. Blood samples were collected from both groups and the measurement of pregnancy specific glycoprotein 1 was done using an enzyme immunometric assay.

The groups of preeclampsia pregnant women had markedly lower pregnancy specific glycoprotein 1 than the women with the uneventful pregnancies (p value < 0.001). Pregnancy specific glycoprotein 1 can significantly predict preeclampsia (P value < 0.001) with an odds ratio of 0.839 and 95% confidence interval of 0.763 – 0.924. By application of receiver operating characteristic curve analysis, it was observed that the cut-off value of pregnancy specific glycoprotien1 for predicting preeclampsia was 10.4 ng/ml with 77% sensitivity and 60% specificity, the area under the curve 0.728 with 95% confidence interval between 0.622 and 0.835, P value < 0.001).

This study had found that women with PE had significantly lower PSG1 levels than the women with the uneventful pregnancies (9.8 vs 14.3 ng/ml; p value < 0.001).

From the results of the present study, it could be concluded that pregnancies complicated by PE are associated with decreased serum maternal level of PSG1, and values <10.4 ng/ml can predict the development of PE with 77% sensitivity and 60% specificity. The abnormally decreased levels of PSG1 in pregnant women with PE might be a reflection of stressed or dysfunctional syncytiotrophoblasts, which is related to the pathogenesis of this placental disorder.

Source: Murad et al. / Indian Journal of Obstetrics and Gynecology Research 2024;11(3):388–392;