Fondaparinux sodium bests low molecular weight heparin for VTE prophylaxis in trauma patients

Results

• Fondaparinux sodium group exhibited lower in-hospital venous thromboembolism and in-hospital minor bleeding compared to low molecular weight heparin group.
• Furthermore, no difference of in-hospital major bleeding, in-hospital death, and venous thromboembolism /bleeding/death within 2 months after discharge was observed between fondaparinux sodium group and low molecular weight heparin group
• Further subgroup analyses identified, in specific cluster of patients such as older age, renal function impairment, hypertension and so on, in-hospital venous thromboembolism was declined in fondaparinux sodium group compared to low molecular weight heparin group

Thus, fondaparinux sodium is probable to exhibit a superior thromboprophylaxis efficacy compared with low molecular weight heparin in in-hospital patients with major orthopedic surgery or trauma, especially in some special patients such as older age, renal function impairment, hypertension, etc.

Reference:

Fondaparinux sodium and low molecular weight heparin for venous thromboembolism prophylaxis in Chinese patients with major orthopedic surgery or trauma: a real-world study by Donglin Fu et al. published in the BMC Surgery

https://doi.org/10.1186/s12893-022-01652-6

Keywords:

Fondaparinux, sodium, low, molecular, weight, heparin, venous, thromboembolism, prophylaxis, Chinese, patients, major, orthopedic, surgery, or trauma, real, world, study, Donglin Fu, Li Li, Yifan Li, Xiaofei Liu, Hongkang Chen, Naitian Wu & Guangfeng Sun, Fondaparinux sodium, Low molecular weight heparin, Venous thromboembolism prophylaxis, Major orthopedic surgery, Trauma, BMC Surgery