- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Early ventricular arrhythmias tied to higher mortality in STEMI patients: Study
France: Early ventricular arrhythmia (EVA) is 5-fold more common than late ventricular arrhythmia (LVA) in STEMI patients and augurs a higher risk of in-hospital all-cause mortality, reveals a recent study. Further, the researchers showed LVA to be mainly associated with the patient's baseline risk profile and surrogate markers of larger infarct size.
Vincent Auffret, University of Rennes, Rennes, France, and the team in their study published in the Archives of Cardiovascular Diseases, developed and internally validated a risk score for identifying patients at high LVA risk for whom early intensive care unit discharge may not be suitable.
Ventricular arrhythmias are one of the serious complications of ST-segment elevation myocardial infarction (STEMI) which can be life-threatening. The study was conducted with the objective to describe the incidence, predictors, and in-hospital impact of EVA (occurring < day 2 after STEMI) and LVA (occurring ≥ day 2 after STEMI) in STEMI patients.
For this purpose, the researchers analyzed data from 13,523 patients enrolled in a prospective registry. To identify predictors of EVA, LVA, and in-hospital all-cause mortality, Logistic and Cox regressions were performed. Predictors of LVA were used to build a risk score.
Following were the study's salient findings:
- EVA occurred in 678 patients (5%), whereas 120 patients (0.9%) experienced LVA, at a median timing of 3 days after STEMI.
- EVA was associated with a significantly higher risk of all-cause mortality (hazard ratio: 1.44), whereas no association was observed with LVA (hazard ratio 0.86). Multivariable predictors of LVA were: age ≥ 65 years; serum creatinine ≥ 85 μmol/L on admission; pulse pressure ≤ 45 mmHg on admission; presence of a Q wave on admission electrocardiogram; Thrombolysis In Myocardial Infarction flow grade < 3 after percutaneous coronary intervention; and left ventricular ejection fraction ≤ 45%.
- The score derived from these variables allowed the classification of patients into four risk categories: low (0–21); low-to-intermediate (22–34); intermediate-to-high (35–44); and high (≥ 45).
- Observed LVA rates were 0.2%, 0.3%, 0.9% and 2.5%, across the four risk categories, respectively. The model demonstrated good discrimination (20-fold cross-validated c-statistic of 0.76) and adequate calibration (Hosmer-Lemeshow).
To conclude, EVA is 5-fold more common than LVA in the setting of STEMI, and portends a higher risk of in-hospital all-cause mortality.
Reference:
The study titled, "Early and late ventricular arrhythmias complicating ST-segment elevation myocardial infarction," was published on the journal Archives of Cardiovascular Diseases.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751