Greater triglyceride-glucose index variability tied to higher risk of cardiovascular disease
China: A higher level of triglyceride-glucose (TyG) and greater TyG variability are both independently associated with a higher risk of cardiovascular disease (CVD), states a recent study. The study was published on ResearchSquare.com as a preprint and has not yet been peer-reviewed.
"By studying the association between long-term TyG variability and CVD risk, earlier recognition of insulin resistance would be possible and reduce CVD risk," the authors wrote in their study.
Recent studies have indicated that the TyG index is an independent predictor of cardiovascular disease. However, there is no information on the impact of long-term visit-to-visit variability in the TyG index on CVD risk. Haibin Li, Beijing Chaoyang Hospital, Capital Medical University, China, and colleagues, therefore, aimed to investigate the longitudinal association between baseline and mean TyG index as well as TyG variability and incident CVD in a Chinese population.
The researchers included 52,925 individuals without previous history of CVD in the Kailuan study who underwent three health examinations (2006, 2008, and 2010). They were followed up for clinical events until 2019. Calculation of TyG index was done as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. TyG variability was measured as the SD of the residuals obtained from a linear regression on the three TyG measurements for each individual.
Salient findings of the study include:
- During a median follow-up time of 9.0 years, 2,745 developed CVD.
- The highest tertile (T3) of baseline and mean TyG index were each associated with higher CVD incidence as compared with the lowest tertile (T1) group: aHR, 1.35 and aHR, 1.42, respectively.
- Tertile 3 of TyG variability was associated with increased CVD incidence compared to the T1 group (aHR, 1.13).
- Individuals in the highest tertile of baseline TyG and the highest tertile of TyG variability experienced the highest incidence of CVD (aHR, 1.30).
To conclude, higher TyG levels and greater TyG variability are independently associated with a higher incidence of CVD risk.
Reference:
The preprint research study titled, "Triglyceride-Glucose Index Variability and Incident Cardiovascular Disease: A Prospective Cohort Study," was published on ResearchSquare.com.
