- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Intensive BP lowering reduces ED visit or hospitalization in HFpEF as well as HFrEF: Study
Intensive BP treatment is associated with reduced acute decompensated heart failure (ADHF) events in the SPRINT (Systolic Blood Pressure Intervention Trial).
A new study shows that in the SPRINT study, intensive blood pressure reduction reduced both acute decompensated preserved ejection fraction (HFpEF) and reduced EF (HFrEF) events. Following an initial incident ADHF, the rates of subsequent hospitalization and mortality were high, and they were comparable for those who developed HFpEF or HFrEF. In either HFpEF or HFrEF, randomization to the intensive arm had no effect on the risks of subsequent all-cause or heart failure events. Age and Black race were independent predictors of clinical outcomes among those who developed HFpEF.
This study was conducted by Bharathi Upadhya and team with the objective to report on the effect on HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) and their subsequent outcomes. The findings of this study were published in the Circulation: Heart Failure on 26th November, 2021.
The Incident ADHF was defined in this study as a hospitalization or emergency department visit that was confirmed and formally adjudicated by a blinded events committee using standardized protocols. HFpEF was defined as EF45 percent, while HFrEF was defined as EF45 percent.
The results were stated as follows:
Among the 133 participants with incident ADHF who underwent EF assessment, 69 (52%) had HFpEF and 64 (48%) had HFrEF (P value: 0.73).
During an average of 3.3 years of follow-up, rates of subsequent all-cause and HF hospital readmission and mortality were high in those who developed incident ADHF, but there were no significant differences between those who developed HFpEF versus HFrEF.
Regardless of EF subtype, randomization to the intensive arm had no effect on subsequent mortality or readmissions after the initial ADHF event.
Although the relatively small number of events limited statistical power, age was an independent predictor of all-cause mortality, and Black race was an independent predictor of all-cause and HF hospital readmission during follow-up among participants who developed HFpEF.
In conclusion, in patients with HF who had either a HFpEF or a HFrEF, intensive blood pressure lowering reduced the episodes of acute decompensated HF (ADHF). Given the scarcity of HFpEF treatments and the poor prognosis, treating hypertension to prevent HFpEF is critical.
Reference:
Upadhya, B., Willard, J. J., Lovato, L. C., Rocco, M. V., Lewis, C. E., Oparil, S., Cushman, W. C., Bates, J. T., Bello, N. A., Aurigemma, G., Johnson, K. C., Rodriguez, C. J., Raj, D. S., Rastogi, A., Tamariz, L., Wiggers, A., & Kitzman, D. W. (2021). Incidence and Outcomes of Acute Heart Failure With Preserved Versus Reduced Ejection Fraction in SPRINT. In Circulation: Heart Failure. Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circheartfailure.121.008322
Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751