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Noncontrast CT better alternative to CTA for predicting Hematoma expansion in ICH
A new study found that in intracerebral hemorrhages for identifying hematoma expansion non contrast computed tomography hypodensities are better alternatives to CTA spot signs as non-contrast CT hypodensities significantly add value and predict hematoma expansion. The study results are published in the journal Stroke. Previous literature shows that in intracerebral hemorrhage...
A new study found that in intracerebral hemorrhages for identifying hematoma expansion non contrast computed tomography hypodensities are better alternatives to CTA spot signs as non-contrast CT hypodensities significantly add value and predict hematoma expansion.
The study results are published in the journal Stroke.
Previous literature shows that in intracerebral hemorrhage non-contrast computed tomography hypodensities are a better predictor of hematoma expansion (HE) and a possible alternative to the computed tomography angiography (CTA) spot sign but there is uncertainty on the added value to available prediction models. Hence researchers conducted a multicenter study to investigate whether the inclusion of hypodensities improves the prediction of HE and compared their added value over the spot sign.
A multicenter, retrospective analysis was carried out at 8 university hospitals on patients admitted for primary spontaneous intracerebral hemorrhage.
Logistic regression analysis was used to explore the predictors of HE like the hematoma growth >6 mL and/or >33% from baseline to follow-up imaging. The discrimination of a simple prediction model for HE based on 4 predictors (antiplatelet and anticoagulant treatment, baseline intracerebral hemorrhage volume, and onset-to-imaging time) before and after the inclusion of non-contrast computed tomography hypodensities, were compared using the receiver operating characteristic curve and De Long test for the area under the curve comparison.
- A total of 2465 subjects were included, of whom 664 (26.9%) had HE and 1085 (44.0%) had hypodensities.
- After adjustment for confounders in logistic regression, hypodensities were independently associated with HE.
- The discrimination of the 4 predictors model improved with the inclusion of non-contrast computed tomography hypodensities.
- The added value of hypodensities was statistically significant but the addition of the CTA spot sign did not provide significant discrimination improvement in the subgroup of CTA patients (n=895, 36.3%).
Thus, non-contrast computed tomography hypodensities can be used to stratify the risk of HE with good discrimination without CTA.
Further reading: Morotti A, Boulouis G, Nawabi J, et al. Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion [published online ahead of print, 2023 Jan 9]. Stroke. 2023;10.1161/STROKEAHA.122.041302. doi: 10.1161/STROKEAHA.122.041302
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at email@example.com.