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  • Oxidized LDL, CRP and...

Oxidized LDL, CRP and cholesterol may help in early detection of Coronary Heart Disease

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-06-07T19:30:27+05:30  |  Updated On 7 Jun 2022 7:30 PM IST
Oxidized LDL, CRP and cholesterol may help in early detection of Coronary Heart Disease
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A new study published in the Journal of the Association of Physicians of India of India shows that, high oxidized LDL (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and remnant lipoprotein cholesterol (RLP-C) levels associate with atherogenesis in coronary heart disease patients (CHD).

Coronary heart disease is a prominent disease entity in the Indian population, accounting for considerable death and morbidity. In India, the prevalence of CHD is growing. The oxidative changes in low-density lipoproteins have been associated with artery hardening. The conversion of LDL to oxidized LDL is a critical stage in the oxidation theory of atherogenesis. Oxidized LDL and residual lipoprotein cholesterol induced atherosclerosis by stimulating immunological and inflammatory responses. Because of their smaller size, high cholesterol content, and longer residence time in the circulation, residual lipoproteins are extremely atherogenic. When compared to LDL particles, remnant lipoproteins transfer more cholesterol to macrophages. Remnant lipoproteins easily infiltrate the artery wall and are promptly picked up by macrophages. This causes foam cells to develop, kicking off the lipid-laden plaque. C-reactive protein is a nonspecific inflammatory measure with a high sensitivity. Oxidized LDL, RLP-C, and high-sensitivity C-reactive protein all play important roles in the pathogenesis of CHD.

As a result, Thirnavukkarasu Jaishankar and colleagues undertook this study to evaluate ox-LDL and RLP-C as prospective biomarkers in the progression of CHD.

This cross-sectional study was done on participants appearing for master health check-up and medicine at Sri Ramaswamy Memorial Medical College Hospital and Research Center. This cross-sectional study included 273 individuals who were 45 years old and of the same gender. As controls, 91 non-diabetic people with CHD, 91 diabetic subjects with CHD, and 91 normal healthy participants were chosen. After an overnight fast, bodily fluid samples were obtained for lipid profile, ox-LDL, and hs-CRP analyses. The enzyme-linked immunosorbent assay (ELISA) technique was used to evaluate oxidized LDL and hs-CRP, and the Auto Analyzer AU480 was used to measure the lipid profile. For the comparison of two groups, statistical analysis was performed using the Student's t-test and Pearson's correlation analysis.

The key findings of this study were as follow:

1. The CHD group had substantially higher mean levels of ox-LDL, RLP-C, and hs-CRP.

2. There was a substantial positive connection between plasma ox-LDL, RLP-C, and hs-CRP.

The current study concludes that measuring RLP-C, ox-LDL, and hs-CRP may help to detect CHD earlier and lower morbidity and mortality risk. The revelation of its relationship with RLP-C, ox-LDL, hs-CRP, hypertension, dyslipidemia, and diabetes is currently causing worry.

Reference:

Jaishankar T, Shivasekar M, Vinodhini VM. Assessment of Remnant Lipoprotein Cholesterol and Oxidized Low-density Lipoprotein Associated with Low-grade Inflammation in Coronary Heart Disease Subjects of Young South Indian Population. J Assoc Physicians India 2022;70(6):15–19.

Journal of the Association of Physicians of India (JAPI)C-reactive proteincoronary heart disease
Source : Journal of the Association of Physicians of India
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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