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Preeclampsia in younger women tied to risk of coronary atherosclerosis: JACC
Denmark: Younger women with previous preeclampsia are at a slightly higher risk of coronary atherosclerosis compared with women in the general population, states a recent study in the Journal of the American College of Cardiology. After adjusting for traditional cardiovascular risk factors, preeclampsia remained an independent risk factor.
Previous studies have shown women with previous preeclampsia to be at increased risk of coronary artery disease later in life. Maria G. Hauge, Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, and colleagues, therefore, aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population.
For this purpose, the researchers matched women aged 40-55 years with previous preeclampsia in a 1:1 on age and parity with women from the general population. Participants completed a clinical examination, an extensive questionnaire, and a coronary computed tomography angiography (CTA). The prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in the case of a nondiagnostic coronary CTA was the main study outcome.
The findings of the study were as follows:
- A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population).
- Women with previous preeclampsia were more likely to have hypertension (40.1% vs 22.8%), dyslipidemia (47.7% vs 41.7%), diabetes mellitus (3.4% vs 1.1%), and high body mass index (27.3 ± 5.7 kg/m2 vs 25.0 ± 4.2 kg/m2).
- Cardiac computed tomography was performed in all women.
- The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (27.4% vs 20.0%) with an OR: 1.41 after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity.
"Younger women with a history of preeclampsia are at a higher prevalence of coronary atherosclerosis compared with women from the general population," the researchers wrote. "Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors."
Reference:
Hauge MG, Damm P, Kofoed KF, Ersbøll AS, Johansen M, Sigvardsen PE, Møller MB, Fuchs A, Kühl JT, Nordestgaard BG, Køber LV, Gustafsson F, Linde JJ. Early Coronary Atherosclerosis in Women With Previous Preeclampsia. J Am Coll Cardiol. 2022 Jun 14;79(23):2310-2321. doi: 10.1016/j.jacc.2022.03.381. PMID: 35680182.
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751