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  • Single intraoperative...

Single intraoperative IV dose of methadone safe and may not prolong QTc significantly in cardiac surgical patients: Study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-23T08:45:58+05:30  |  Updated On 23 Dec 2024 11:33 AM IST
Single intraoperative IV dose of methadone safe and may not prolong QTc significantly in cardiac surgical patients: Study
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Researchers have determined that intraoperative intravenous methadone does not prolong the corrected QT interval (QTc) or increase the risk of arrhythmias in adult cardiac surgery patients. Methadone is an opioid often used for pain management; however, its potential QTc prolongation has raised safety concerns in populations at high risk, such as cardiac surgery patients. A recent study was conducted by McClain and colleagues which was published in the Journal of Cardiothoracic and Vascular Anesthesia.

A total of 1,040 adult patients who underwent elective cardiac surgery between July 2020 and July 2023 at a tertiary academic medical institution were studied. Among those, 423 received intraoperative methadone 0.1 mg/kg and 617 other types of analgesics, as part of the enhanced recovery after cardiac surgery (ERACS) pathway. This retrospective cohort study used validated institutional electronic medical record data to study the perioperative effects of intravenous methadone. All adult patients undergoing elective cardiac surgery were included in this study and divided into two groups: those who received methadone and those who did not.

Main outcomes measu

• Primary Outcomes: Change in QTc and percentage QTc change between preoperative and postoperative measurements during intensive care unit admission.

• Secondary Outcomes: Intraoperative ventricular and atrial arrhythmias, length of stay in the ICU, 30-day mortality, 1-year mortality, and days to death.

• QTc intervals were measured before surgery, and immediately and at 24 hours postoperatively to determine the presence of significant differences and trends between the groups.

Key Findings

QTc Interval Changes

• QTc was prolonged at postoperative day one but resolved at 24 hours postoperative in the methadone and the nonmethadone cohorts.

• No significant differences in baseline QTc, immediate postoperative QTc, changes in QTc, or percent QTc changes were observed between groups.

Incidence of Arrhythmias

• No significant differences were noted postoperatively between the groups on ventricular arrhythmias and atrial fibrillation

Mortality Rates

• The groups were not significantly different when comparing 30-day mortality, 1-year mortality, days to death

• Days to death were comparable between the two groups.

Safety Profile

• The results verified that a single dose of methadone given in the operating room at a dose of 0.1 mg/kg does not significantly contribute to QTc prolongation and is not associated with an increased risk of arrhythmias.

A single dose of intraoperative intravenous methadone (0.1 mg/kg) was safe for adult cardiac surgical patients, with no significant prolongation or increased risk of arrhythmias on QTc intervals. These results bring out the potential of methadone as a safe analgesic in enhanced recovery pathways for cardiac surgery, addressing concerns regarding its impact on cardiac electrophysiology.

Reference:

McClain, M. R., Subramaniam, K., Cheema, R., Lavage, D. R., Lin, H.-H. S., Sultan, I., Sadhasivam, S., & Howard-Quijano, K. (2024). Intraoperative methadone in adult cardiac surgical patients and risks for postoperative QTc prolongation. Journal of Cardiothoracic and Vascular Anesthesia. https://doi.org/10.1053/j.jvca.2024.11.012

Journal of Cardiothoracic and Vascular AnesthesiaMethadoneQTc IntervalCardiac SurgeryArrhythmiasEnhanced RecoveryPostoperative Safety
Source : Journal of Cardiothoracic and Vascular Anesthesia
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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