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  • Thiamine may improve...

Thiamine may improve left ventricular function in alcoholic cardiomyopathy: Study

Dr Kartikeya KohliWritten by Dr Kartikeya Kohli Published On 2021-07-21T18:15:20+05:30  |  Updated On 21 July 2021 6:18 PM IST
Thiamine may improve left ventricular function in alcoholic cardiomyopathy: Study
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Alcoholic cardiomyopathy (ACM) is a chronic dilated heart disease with decreased left ventricular ejection fraction(LVEF). A recent study by Oruganti Sai Satish et al points out that cardiomyopathy when treated with thiamine showed beneficial results. The study has been published in the Indian Heart Journal.

The objective of the study was to study the efficacy of thiamine supplementation along with standard medical therapy in ACM patients and reversibility of left ventricular systolic dysfunction. The study was conducted in Department of Cardiology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.

The study included 11 newly diagnosed patients with ACM. Patients with a first episode of acute heart failure with history of chronic heavy drinking of alcohol i.e, more than 5 years of duration with greater than 80 mg/day were included. They were treated with 3 days of intravenous(IV) therapy with thiamine followed by oral supplementation.

The researchers found that The average amount of alcohol consumed per day was 60e110 g/day over a mean duration of 14 years. LVEF was 30% at baseline which improved by 45% and 53% along with reduction in LV dimensions over 3 and 6 months respectively.

The researchers concluded that the study suggests the role of thiamine supplementation along with standard medical therapy in improvement of LVEF in alcoholic cardiomyopathy patients with acute HF.

For further information :

Oruganti Sai Satish, Shabbir Ali Shaik "Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy" Indian Heart Journal 73 (2021) 389-391.

Left ventricular dysfunctioncardiomyopathycardiovascularthiaminealcohol abuse
Dr Kartikeya Kohli
Dr Kartikeya Kohli

    Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.

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