Thiamine supplementation reduces delirium in ICU patients: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-07-07T10:15:48+05:30 | Updated On 7 July 2021 11:06 AM IST

USA: Thiamine supplementation may reduce the risk of delirium in critically ill patients, suggests a recent review in the Journal of Critical Care. However, thiamine supplementation did not reduce overall mortality, and mortality in sepsis patients.

Previous studies have shown thiamine supplementation to be beneficial in critically ill patients. In order to fully appraise the available data, Yub Raj Sedhaia, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA, and colleagues performed a meta-analysis of 18 published studies.

The researchers conducted a thorough systematic search. The studies enrolling critically ill patients receiving thiamine supplementation were compared with the standard of care (SOC) group. RevMan 5.4 was used for data analysis.

A total of eighteen studies (8 RCTs and 10 cohort studies) met the criteria for quantitative synthesis.

Also Read: No notable benefit of Vitamin C, thiamine, steroids combo in septic shock: JAMA

Key findings of the study included:

In the analysis of RCTs, thiamine supplementation showed 42% lower odds of developing ICU delirium (OR 0.58).
A reduction in mortality was observed on performing fixed-effect model analysis, however, a level of statistical significance could not be reached on performing random effect model analysis (OR, 0.78).
Further sub-group analysis of 13 studies in patients with sepsis, there was no difference in mortality between the two groups (OR, 0.83).

Our findings showed that thiamine supplementation in critically ill patients led to a reduction in the incidence of ICU delirium among RCTs. However, there was no significant benefit in terms of overall mortality, and mortality in patients with sepsis," they wrote. "Further, large scale randomized prospective studies are warranted to investigate the role of thiamine supplementation in critically ill patients."

Also Read: Melatonin improves sleep quality and benefits ICU patients: Study

Reference:

The study titled, "Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis," is published in the Journal of Critical Care.

DOI: https://www.sciencedirect.com/science/article/abs/pii/S0883944121001039

Journal of Critical Caredeliriumcritically illthiamine

Source : Journal of Critical Care

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751