Microneedle patch with 5% topical lidocaine gel reduces dental pain of infiltration: Study
Researchers have recently found out that prior oral application of a microneedle patch combined with 5% topical lidocaine gel reduces the pain experienced from dental infiltration. The study is published in the Journal of Dentistry. Sinead Daly and colleagues from the Clinical Trials Unit, Bristol Dental Hospital, Lower Maudlin Street, Bristol, United Kingdom conducted this study...
Researchers have recently found out that prior oral application of a microneedle patch combined with 5% topical lidocaine gel reduces the pain experienced from dental infiltration.
The study is published in the Journal of Dentistry.
This proof of principle randomised, two-treatment, double-blind, crossover split-unit design study in 16 healthy participants investigated levels of perceived pain from 3 increasing pain provoking challenges, when topical 5% lidocaine dental gel was applied to the oral mucosa with a microneedle patch and a patch with no microneedles, prior to infiltration with local anaesthesia on 2 visits. In the end, only 15 participants completed the study. Pain was assessed by visual analogue scale (VAS) and 4-point verbal rating scale (VRS).
The authors revealed the following findings-
a. Mean pain scores, lower at buccal sites, increased in both groups across challenges 1−3: Test palatal 5.1, 11.9, 26.8; buccal 0.7, 2.8, 18.3; Control palatal 12.3, 18.7, 39.5; buccal 4.0, 6.9, 30.6.
b. The microneedle patch plus lidocaine significantly lowered VAS pain scores at both sites for all challenges, the biggest mean difference seen palatally after challenge 3 (12.7, p < 0.001).
c. VRS pain scores were also significantly reduced for test compared to control for all 3 challenges (p = 0.014).
d. Buccal scores favoured the microneedle patch, significantly for pain challenge 3 (p = 0.025).
e. No adverse events occurred.
Therefore, the authors concluded that "Microneedle patch use in the dental setting offers the prospect of improving degree and depth of anaesthesia from topically applied anaesthetic gel, without itself causing any pain. Prior oral application of a microneedle patch combined with 5% topical lidocaine gel reduced the pain experienced from dental infiltration."
Dental injections are associated with fear and anxiety. Application of a microneedle patch, combined with topical anaesthetic, to the oral mucosa prior to delivery of the injection reduces the pain from this dental procedure. This novel technique may allay patients' apprehension of local anaesthesia and improve quality of life outcomes, they further added.
BDS, MDS( Pedodontics and Preventive Dentistry)
Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at email@example.com. Contact no. 011-43720751