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Researchers report a case of porphyria cutanea tarda associated with hepatitis C

Hina ZahidWritten by Hina Zahid Published On 2021-06-19T09:15:48+05:30  |  Updated On 2021-08-23T12:33:52+05:30

Memphis, TN: A recent case study published in the New England Journal of Medicine (NEJM) describes a rare case of porphyria cutaneous yards associated with Hepatitis C. The case is reported by Dr. Tejesh S. Patel and Dr. Evgeniya Teterina Mohammed from the University of Tennessee Health Science Center, Memphis, Tennessee. Porphyria cutanea tarda (PCT) is the most common type...

Memphis, TN: A recent case study published in the New England Journal of Medicine (NEJM) describes a rare case of porphyria cutaneous yards associated with Hepatitis C. 

The case is reported by Dr. Tejesh S. Patel and Dr. Evgeniya Teterina Mohammed from the University of Tennessee Health Science Center, Memphis, Tennessee. 

Porphyria cutanea tarda (PCT) is the most common type of porphyrias. Usually, the disease manifests with dermatological signs, including skin fragility and vesciculo-bullous eruption on the hand and face, which become evident after exposure to sunlight. 

Also Read: Hepatitis C Virus Drugs may augment Covid 19 suppression effect of Remdesevir: Study

The case in question is of a 65-year-old man who was presented to the dermatology clinic with a 6-month history of worsening lesions on his hands and forearms as well as fingernail thickening.

His medical history included end-stage renal disease and untreated hepatitis C virus infection. Physical examination showed crusted erosions and atrophic scars on the dorsal hands and forearms as well as scattered tense vesicles on the fingers and forearms. Onychodystrophy and subungual hyperkeratosis were observed in the fingernails. A 24-hour urine sample showed an elevated level of uroporphyrins (558 μg [672 nmol]; normal range, 0 to 24 μg [0 to 28 nmol]). 

A diagnosis of porphyria cutanea tarda was made. Porphyria cutanea tarda is due to acquired or inherited uroporphyrinogen decarboxylase deficiency. Risk factors for acquired disease include alcohol use, hepatitis C or human immunodeficiency virus infection, smoking, and certain medications.

Treatment for hepatitis C virus infection with sofosbuvir–velpatasvir was initiated, and the patient was advised to avoid exposure to the sun. At follow-up 4 months after presentation, the patient's skin lesions and fingernail changes had abated. He had only minimal residual blistering on his forearms. 

Also Read: Treatment of Chronic Hepatitis C in Young Children Reduces Adverse Outcomes: Study

Reference:

The case study titled, "Porphyria Cutanea Tarda Associated with Hepatitis C," is published in the New England Journal of Medicine.

DOI: https://www.nejm.org/doi/full/10.1056/NEJMicm2035140

DOI: 10.1056/NEJMicm2035140

porphyria cutanea tarda hepatitis b sofosbuvir–velpatasvir NEJM 
Source : New England Journal of Medicine
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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