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  • Increased Skin Cancer...

Increased Skin Cancer Risk in Lower Extremity Lymphedema Patients

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-12-23T07:00:14+05:30  |  Updated On 23 Dec 2023 11:09 AM IST
Increased Skin Cancer Risk in Lower Extremity Lymphedema Patients
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A recent retrospective cohort study conducted at the Mayo Clinic in Rochester, MN, sought to evaluate whether individuals with lower extremity (LE) lymphedema had a higher propensity for skin cancer compared to matched controls without lymphedema. Led by Dr. Nimay C. Anand and colleagues from Meharry Medical College in Nashville, Tennessee, the study spanned from January 2000 to December 2020 and encompassed 4,437 patients with LE lymphedema, alongside age-, race-, and sex-matched controls.

The comprehensive analysis revealed a striking association between LE lymphedema and an increased risk of skin cancer. Patients with lymphedema in their lower extremities exhibited a significantly elevated risk compared to the control group. Specifically, within the subset of patients with unilateral lymphedema, the lymphedematous extremity showed 2.65 times the likelihood of developing skin cancer, particularly basal cell carcinoma, compared to the nonlymphedematous lower extremity.

The findings underscore the importance of vigilance and specialized monitoring for individuals grappling with LE lymphedema. Clinicians caring for these patients should remain vigilant and conduct regular screenings, especially considering the increased risk of skin cancer, including basal cell carcinoma and squamous cell carcinoma, as well as angiosarcoma as anticipated.

The study prompts further investigations into the underlying mechanisms and pathogenesis of skin cancer development in individuals with LE lymphedema. Dr. Anand and the research team emphasized the necessity for future studies to delve deeper into the distinctive aspects of skin cancers arising in lymphedematous lower extremities. This includes exploring whether these cancers exhibit unique histological characteristics or differ in prognostic outcomes compared to those occurring in nonlymphedematous extremities.

The study, published online in Mayo Clinic Proceedings, disclosed associations between some authors and the pharmaceutical industry, emphasizing the need for transparency regarding potential conflicts of interest in medical research.

  • Participants: 4,437 patients with LE lymphedema

  • Risk Association: Lymphedema group showed significantly increased risk of skin cancer compared to matched controls

  • Risk Magnitude: Lymphedematous extremity in unilateral lymphedema showed 2.65 times increased likelihood of skin cancer, notably basal cell carcinoma

This study highlights a critical consideration for clinicians, accentuating the need for tailored monitoring and vigilant care for patients coping with LE lymphedema. Further research is anticipated to illuminate the nuanced aspects of skin cancer development in this demographic, paving the way for more personalized and effective management strategies.

Reference:

Anand, N. C., Campbell, E. H., Baum, C. L., Gibson, L. E., Todd, A., Bradt, J. L., & Alavi, A. Association of lower extremity lymphedema and nonmelanoma skin cancers. Mayo Clinic Proceedings. Mayo Clinic,2023;98(11):1653–1659. https://doi.org/10.1016/j.mayocp.2023.02.030


Mayo Clinic ProceedingsMayo ClinicSkin Cancer RiskLower Extremity LymphedemaBasal Cell CarcinomaSquamous Cell CarcinomaAngiosarcomaPatient MonitoringMedical Research
Source : Mayo Clinic Proceedings
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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