Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Dermatology
  • Dermatology News
  • Prenatal vitamin D...

Prenatal vitamin D supplementation decreases incident atopic eczema in first year of birth

Written By : Dr. Kamal Kant Kohli Published On 2022-11-20T20:00:23+05:30  |  Updated On 26 Nov 2022 12:19 PM IST
Pregnancy vitamin D supplementation and offspring bone mineral density
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

U.K.: According to a study published in the British Journal of Dermatology, administering mothers 1000 IU of cholecalciferol daily from 14 weeks of pregnancy till delivery resulted in a lower incidence of atopic eczema in the first year of life.

A surge in atopic eczema prevalence has been seen globally in recent decades, with estimates of prevalence ranging from 95% in children under the age of 4 to 16.5% in children ages 1 to 5.

With conflicting data, maternal vitamin D status has been extensively related to child risk of developing atopic eczema and other atopic illnesses. Maternal serum levels of 25-hydroxyvitamin D [25(OH)D] correspond with offspring levels at birth.

The researchers sought to determine whether maternal cholecalciferol supplementation during pregnancy affected the likelihood that the offspring would develop atopic eczema at ages 12, 24, and 48 months.

"Our findings offer the first randomized controlled trial substantiation of a protective benefit of antenatal cholecalciferol supplementation on the likelihood of infantile atopic dermatitis, an effect that may be mediated by elevated levels of cholecalciferol in breast milk," Keith M. Godfrey and colleagues wrote.

For this purpose, In the double-blind, randomized, placebo-controlled UK Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial, the researchers examined the link between maternal vitamin D supplementation during pregnancy and offspring atopic eczema at ages 12, 24, and 48 months. From roughly 14 weeks of pregnancy until delivery, pregnant women in the MAVIDOS study were randomly assigned to receive either 1000 IU of cholecalciferol per day or a matched placebo, with the primary outcome being the amount of bone mineral content in the newborn. At ages 12 (n = 635), 24 (n = 610), and 48 (n = 449) months, the prevalence of atopic eczema in the offspring was determined using the UK Working Party criteria for the definition of atopic dermatitis.

Major highlights of the trial:

  • Except for the intervention group's extended duration of breastfeeding, mothers' and children's characteristics were comparable between the intervention and placebo groups.
  • At age 12 months, children of mothers who received 1000 IU of cholecalciferol daily had a lower odds ratio (OR) of atopic eczema [OR 055, 95% confidence interval (CI) 032-097, P = 0.04] after accounting for the duration of breastfeeding; this effect waned and was not statistically significant at ages 24 months (OR 076, 95% CI 047-123) or 48 months (OR 0·75, 95% CI 0·37–1·52).
  • stratification revealed a decreased risk of infantile eczema in the intervention group for infants breastfed for ≥ 1 month (OR 048, 95% CI 024-094, P = 0.03) but not for those breastfed for <1 month (OR 080, 95% CI 029-217, P = 0.66).
  • This was true even though the statistical interaction of intervention and breastfeeding period in reference to eczema at age 12 months was not significant (P = 0·41).

The authors in their conclusion stated that with the best evidence for the prevention of neonatal hypocalcaemia and evolving research for effects on other health outcomes impacting the skeletal, respiratory, and immunological systems, numerous international and national guidelines advise taking cholecalciferol 400-600 IU daily (10-15 g) during pregnancy.

The results show that atopic eczema has a developmental component and indicate at a prenatal component that may be controllable.

REFERENCE

El-Heis, S., D'Angelo, S., Curtis, E.M., Healy, E., Moon, R.J., Crozier, S.R., Inskip, H., Cooper, C., Harvey, N.C., Godfrey, K.M. and (2022), Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial. Br J Dermatol, 187: 659-666. https://doi.org/10.1111/bjd.21721

Atopic eczemamaternalprenatalvitamin D supplementationBritish Journal of Dermatologycholecalciferollower incidencepregnancyserum 25-hydroxyvitamin Dinfantile atopic dermatitis
Source : British Journal of Dermatology
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

Show Full Article
Next Story

Editorial

Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

Dapagliflozin Shines in Post-TAVI Patients:DAPA-TAVI Trial Findings

Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension, Dyslipidemia, and Familial ASCVD Risk

Identifying Candidates for Aspirin in Primary Prevention: Men Aged 40-50 with Hypertension,...

Featured image representing thinking

Is Pharma Marketing Going Through "Thinking Recession"?

Beyond BMI: Why Pioglitazone Deserves a Place in Managing Thin-Fat Type 2 Diabetes in India

Beyond BMI: Why Pioglitazone Deserves a Place in Managing 'Thin-Fat' Type 2 Diabetes in India

How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

How to Improve Adherence in Hypertensive Patients? Bridging the Gap with CONNECT Tool

View All

Journal Club Today

Sensitive Skin Explained: Signs, Triggers and Skincare Tips by Dr. Aparajita Lamba

Sensitive Skin Explained: Signs, Triggers and Skincare Tips by Dr. Aparajita Lamba

View All

Health News Today

Health Bulletin 5/July/ 2025

Health Bulletin 5/July/ 2025

View All
© 2022 All Rights Reserved.
Powered By: Hocalwire
X
We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok