Probiotics decreases atopic dermatitis risk in infants having family history: Study
China: Probiotics are beneficial for reducing the risk of atopic dermatitis (AD) in infants with a family history of the condition, finds a recent study published in the journal Archives of Medical Science.
The study by Jia-huan He, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China, and colleagues aimed to investigate the preventive effects of probiotics' oral administration on the severity and incidence of atopic dermatitis in infants.
The study included a total of 396 full-term infants. They were assigned to two groups; 132 newborns without a family history of AD were included in Group A and other 264 newborns were randomly divided into groups B and C. Those in group A and B were only breastfed while those in group C were administered probiotics in addition to breastfeeding.The information of all subjects was recorded, and the incidence of AD was followed up. The levels of serum IgE and IL-4 were measured at the age of 3 years.
Key findings of the study include:
- The incidence of AD in infants in group B was higher than that in group A at 3 months, 4–6 months, and 7–36 months after birth, together with increased symptom scores.
- For infants in group C, the incidence of AD at 4–6 months and 7–36 months after birth and the SCORAD scores at 0–3 months and 4–6 months after birth were lower than those in group B.
- The levels of IgE and IL-4 in group B were higher than those in groups A and C at 36 months old.
"Probiotics addition could favor the establishment of the intestinal microecological balance in the neonatal period, thereby reducing the incidence of AD, decreasing the levels of serum immune indexes and alleviating the severity of the disease," wrote the authors.
"Clinical study on prevention of atopic dermatitis by oral administration of probiotics in infants," is published in the journal Archives of Medical Science.