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  • Psoriasis associated...

Psoriasis associated with nonalcoholic fatty liver disease: JAMA

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-07-26T20:00:51+05:30  |  Updated On 26 July 2022 8:07 PM IST
Psoriasis associated with nonalcoholic fatty liver disease: JAMA
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Psoriasis is associated with nonalcoholic fatty liver disease (NAFLD) according to a recent study published in the JAMA Dermatology.

Recent studies have shown an association between psoriasis and nonalcoholic fatty liver disease (NAFLD) in US inpatients, but the association is still unclear in the outpatient US population.

A study was conducted to assess whether psoriasis is associated with nonalcoholic fatty liver disease in outpatient US adults.

This population-based cross-sectional study used data on US adults aged 20 to 59 years from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2009-2014 cycles. Data were analyzed from June to September 2021.

Results:

  • Among 5672 adults included in this study, 148 (3.0%) had psoriasis and 5524 (97.0%) did not have psoriasis. A total of 1558 participants (26.8%) were classified as having nonalcoholic fatty liver disease.
  • Compared with participants without psoriasis, those with psoriasis had a higher prevalence of nonalcoholic fatty liver disease
  • In a multivariable logistic regression model adjusted for age, sex, race and ethnicity, educational level, family income, marital status, NHANES cycles, diabetes, metabolic syndrome, and smoking and alcohol drinking status, psoriasis was associated with NAFLD
  • In subgroup analyses, psoriasis was associated with nonalcoholic fatty liver disease among men among those aged 20 to 39 years and among those without diabetes
  • An association between psoriasis and nonalcoholic fatty liver disease was found in sensitivity analyses that excluded potential hepatotoxic medication use or non-Hispanic Black participants, redefined nonalcoholic fatty liver disease based on the hepatic steatosis index score and used inverse probability of treatment weighting

Thus, the researchers concluded that in this cross-sectional study, psoriasis was associated with nonalcoholic fatty liver disease in the outpatient US adult population in adjusted models. This association may be important to consider in the context of clinicians prescribing potentially hepatotoxic medication for psoriasis management.

Reference:

Ruan Z, Lu T, Chen Y, et al. Association Between Psoriasis and Nonalcoholic Fatty Liver Disease Among Outpatient US Adults. JAMA Dermatol. 2022;158(7):745–753.

doi:10.1001/jamadermatol.2022.1609

PsoriasisNonalcoholic Fatty Liver DiseaseOutpatientJAMA Dermatology
Source : JAMA Dermatology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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